Tremor: The
Basic Facts
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by Lorna Smedman
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Some people with multiple sclerosis
experience tremor, an involuntary rhythmic shaking movement of the
muscles. The most common type of tremor seen in people with MS is caused
by loss of myelin
on nerve fibers in the cerebellum, specifically the part called the
thalamus, which is responsible for voluntary muscle movement and
balance.
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Some people with multiple sclerosis
experience tremor, an involuntary rhythmic shaking movement of the
muscles. The most common type of tremor seen in people with MS is caused
by loss of myelin
on nerve fibers in the cerebellum, specifically the part called the
thalamus, which is responsible for voluntary muscle movement and
balance.
Tremor can affect the limbs, head,
body, or the muscles needed for speech. Some tremors are slight and
don't interfere with daily living while other tremors can significantly
affect important activities. Gross tremor is characterized by wide back
and forth motions, usually of the arms or legs. Intention or action
tremors are activated when a person reaches for something. When tremor
is severe, it can prevent a person from eating, writing, speaking
clearly, or walking easily.
There is no cure for tremor, and it
remains one of the most frustrating MS symptoms. Options for management
include physical and occupational therapy techniques, drug therapy,
stress management, neurosurgery, and electrode implants. Some of these
options will work for one individual; others will not. Coping with
tremor requires patience, good communication with health-care
professionals, and some creative problem solving.
Don Denton, of Lubbock, Texas, has
been dealing with intention tremors due to his MS for over 20 years.
He's worked as a peer counselor with his chapter of the National
Multiple Sclerosis Society. When he talks to people who have problems
with MS tremor, he tells them frankly that there is no easy answer.
However, he also reassures them that they may be able to reduce these
problems. Don has found some relief with drug therapy. He has also
learned strategies that allow him to perform daily tasks better, and he
plans ahead so that tremor-related problems don't take him by surprise.
For Don, tremor has become just one piece of his challenging chronic
disease.
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Occupational
and physical therapy techniques
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An occupational therapist or
physical therapist is the recommended source for both practical
strategies and adaptive aids that can reduce the negative impact of
tremor on daily life. Your doctor should be able to refer you to a
professional with MS experience—or, call the National MS Society.
Some tremor can be controlled
through the use of braces. A rigid brace can control and support an
affected limb while a person performs a specific activity. Afterwards,
the brace can be removed. In some cases, however, bracing may actually
increase spasticity.
Consult your rehabilitation specialist.
Some people find it helpful to hold
their arms close to the body or to prop an elbow against the chest in
order to gain more control over forearm movements. Weights fastened to
the wrists or ankles with Velcro strips can stabilize an affected limb.
Weighted boots are also an option. Putting weights on canes or walkers,
or using weighted spoons or forks, can make these tools easier to use
when tremor is active. Using weighted devices has to be balanced against
the added fatigue they might cause. Therapists commonly offer samples
for a try-out.
Adaptive equipment, such as wrist
rests that facilitate writing or typing, and plates and cups with lips
to minimize food spills, are also helpful to some people.
Physical or occupational therapists
may be able to reduce the effects of tremor by teaching specific
positions for some activities or by balance and coordination exercises.
These might include repeating a series of movements related to an
activity like eating, for example, until those muscles "learn"
a pattern sufficiently well to override disruptions of the nervous
system. Other exercises might focus on stimulating the balance centers
of the brain. Computers can provide biofeedback that helps people
recognize balance problems in time to compensate for them.
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Tremor and
speech problems
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If tremor affects
the muscles necessary for speech, a person will want to consult a speech
therapist. A speech therapist can show a person how to slow down or
concentrate on phrasing so that speech is more intelligible. If this is
not possible, a person with speech tremor may need to learn alternative
communication skills. Electronic aids, communication charts, or
computer-assisted alternative communication systems are available.
However, tremor this severe is not common.
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Stress management and tremor
People with
MS-related tremor may find that the unwanted muscle movements are worse
in stressful situations. As Dr. Robert R. Young, professor of neurology
at the University of Southern California, explains, "Stress,
excitement, and anxiety all result in the body releasing adrenalin which
produces a temporary aroused condition. All of us experience it at some
time. Stage fright is one example." For people with MS tremor, this
temporary condition can make the existing tremor worse. Stress
management techniques can be an essential tool for such situations. Dr.
Young would also prescribe an adrenergic blocking agent such as
propranolol (Inderal) in pill form for someone who is facing a
particularly stressful event, such as giving a speech or appearing in
public.
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Drug treatments
for the management of tremor
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At present, there
are no drug therapies specifically for tremor, but several drugs have
been shown to have secondary effects that can be more or less helpful.
Some people respond well to one drug; some benefit from a combination;
some find no benefit. People with tremor will have to work patiently
with their physicians in investigating which drug therapy might be
useful to them.
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Drugs used to
treat tremor
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[Adapted from
Symptom Management in Multiple Sclerosis, 3rd Edition, Randall T.
Schapiro, MD, 1998, Demos Medical Publishing Co., Inc., p. 48.]
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- Hydroxyzine
(Atarax, Vistaril)
Antihistamine that can help minor tremor worsened by stress
- Clonazepam
(Klonopin)
Anti-anxiety agent with sedative effect
- Propranolol
(Inderal)
Beta-blocker that provides modest relief for some tremor
- Buspirone
(Buspar)
Anti-anxiety agent with some anti-tremor effect
- Ondansetron
(Zofran)
Anti-nausea drug with anti-tremor effect, but very expensive
- Primidone
(Mysoline)
Antiepileptic drug with some anti-tremor effect in low doses; heavy
sedating effect
- Acetazolamide
(Diamox)
Diuretic; some help for postural tremor
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Other drugs include gabapentin
(Neurontin), isoniazid
(Laniazid, in the US; Isotamine in Canada); and trihexyphenidyl (Artane).
Some gross tremor can also be treated with baclofen,
which is primarily an agent for treating spasticity.
Researchers are studying the effect
of marijuana on tremor. Preliminary studies in lab animals support the
stories some people tell about tremor relief from marijuana. However,
until an alternative delivery system can be developed to protect lungs
from smoke damage, it remains a dangerous as well as an unproven and
illegal therapy.
The National MS Society recommends
that people diagnosed with a relapsing-remitting course of MS begin
treatment with one of the disease-modulating drugs. These drugs may not
have any direct effect on existing symptoms, including tremor, but they
slow down the progress of the disease and help avoid additional damage
to central nervous system tissue.
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Thalamotomy and
deep brain stimulation
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Tremor in MS occurs when there is
damage to nerve fibers in the section of the brain called the thalamus. A
neurosurgical technique called thalamotomy involves permanently destroying
targeted nerve tissue in the thalamus. Thalamotomy can be performed with a
gamma knife, a machine that focuses gamma radiation on a very small point
to destroy targeted tissue. Performed without open-skull surgery or
anesthesia, the procedure is considered to be low risk. The benefits are
more problematic. About two-thirds of people with MS benefit from this
procedure, but many people find that their tremor returns. Because
thalamotomy is not reversible and the positive effects may lessen or stop
over time, many physicians are reluctant to recommend it.
There has been some success reported
in the treatment of MS tremor with electrode stimulation of areas in the
thalamus. This is called deep brain stimulation or DBS. A tiny electrode
is implanted in a carefully targeted area of the thalamus during
open-skull surgery. The electrode is connected to a wire lead that is
inserted under the skin of the neck. It connects to a control device
inserted under the skin in the chest area. This device is programmed to
send impulses to the electrode in the brain. These impulses interfere with
the nerve signals that are causing muscles to make involuntary tremor
movements.
DBS was originally developed for the
treatment of tremor due to Parkinson's disease. It is still a new therapy
and is not yet FDA-approved for MS tremor. When it is used to treat tremor
of the arm, it is unilateral. Only one arm can be treated and the person
must choose which one. Thalamic stimulation to manage leg tremor is also
still in the experimental stage.
Dr. Erwin B. Montgomery, Jr., director
of the Movement Disorders Program and co-director of the Center for
Functional and Restorative Neuroscience at The Cleveland Clinic
Foundation, has performed approximately 40 DBS operations for people with
MS. He is enthusiastic about this new neurosurgical technology, but he
also cautions people to have reasonable expectations about the procedure.
While DBS can significantly reduce tremor, it doesn't abolish the symptom
completely. Like any surgery, this procedure has risks—a 2% to 3% risk
of serious complications due to the surgery itself. Over time, DBS
recipients tend to build up tolerance to a particular electronic signal.
This means that they must frequently return to their doctor's office to
have the impulse generator reset, either to a higher or lower level. This
is done using noninvasive radio signals. Dr. Montgomery advises his
patients to keep all this in mind when they assess the risks and benefits.
Andrea Tucker, of Columbus, Ohio, made
the assessment and decided that the benefits would outweigh the risk of
complications and the bother of frequent office visits. She was often
unable to feed herself or to write due to intention tremor in her arms.
She had tried drug therapies, but found no relief. The fact that the DBS
procedure is reversible helped her decide to try it. In 2000, she had the
operation. Since then, Tucker is eating and writing again. At first, it
was necessary to get her impulse generator reset every few months, but now
this occurs less frequently. She does not find her implanted device
noticeable or intrusive, but she has noticed that her problems with gait
seem to increase when the device is turned on. Tucker simply turns it off
when she needs to walk.
Coping with tremor over the long
termIt can be maddening to
feel that your own body is no longer in your control. Many people feel
painfully embarrassed when other people witness their tremor. Simple
changes—like grasping a glass with two hands instead of one—can be a
big help. Don Denton handles embarrassment by being upfront with people
about all his MS symptoms, including tremor. When ordering coffee at a
restaurant, he'll tell the waitperson, "I can't always control my
hand shaking, so pour me half a cup—otherwise, I'm going to spill
some." Denton also knows that his tremor can increase with fatigue,
so he'll try to plan certain activities for earlier in the day.If tremor
is having an impact on your social life, making you wary about going out
in public, a professional therapist or counselor may help you arrive at
more acceptable solutions.
Keep trying
It's hard to predict which
strategies will work for an individual's tremor. Tremor can interfere with
sexual function, and can be discussed with a physical therapist (PT),
occupational therapist (OT), or healthcare provider. If balance exercises
fail, try biofeedback. If one drug has no effect, or the side effects are
too troublesome, talk to your doctor about other options. Celebrate every
moment of progress—whether it's learning the exact angle needed to sign
your name clearly or reaping benefits from Swiss ball balance exercises.
In dealing with this frustrating
symptom, make use of all the available resources. These include a
responsive healthcare team—therapists, nurses, and counselors as well as
your physician, your family and friends, and the National
MS Society chapter nearest you. Educate yourself and those closest to
you about tremor and all the possible therapies for it, including creative
coping. And try to keep tremor in perspective.
Drug therapies and neurosurgical
technologies now offer somewhat better outcomes for long-term management
of tremor in MS. New developments are expected from research. There is
hope for the future. But until improvements come to fruition, people who
live with tremor will continue to piece together the coping strategies
that best address their own situations.
Written by Lorna Smedman, PhD.
Reviewed by the Client Education Committee of the National MS Society's
Medical Advisory Board.
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© National Multiple
Sclerosis Society, 2002
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